(R)-3-AMINO-5-METHYL-HEXANOIC ACID合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 15 h;
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
ammonium formate; palladium on activated charcoal in methanol
Ambient temperature;
参考文献
El Marini; Roumestant; Viallefont; Razafindramboa; Bonato; Follet
Synthesis, 1992 , # 11 p. 1104 - 1108
反应条件
1: CF3CO2H / CH2Cl2 / 0.5 h / 0 °C
2: HCOONH4 / 10percent Pd-C / methanol / Ambient temperature
View Scheme
参考文献
El Marini; Roumestant; Viallefont; Razafindramboa; Bonato; Follet
Synthesis, 1992 , # 11 p. 1104 - 1108
反应条件
1: 91 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr
2: 97 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C
1.2: 95 percent / tetrahydrofuran; hexane / 3 h / -78 °C
2.1: 91 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr
3.1: 97 percent / trifluoroacetic acid / CH2Cl2 / 15 h / 20 °C
View Scheme
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Enders, Dieter; Wahl, Heiner; Bettray, Wolfgang
Angewandte Chemie, 1995 , vol. 107, # 4 p. 527 - 529
