1,2-二氢-2-氧代喹啉-3-甲醛合成路线 （共 32 条）
反应条件
1: With trichlorophosphate T=80 - 90°C; Vilsmeier-Haack reaction; 16 h; Inert atmosphere; 2: With water; acetic acid T=60°C; Vilsmeier-Haack reaction; Inert atmosphere;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6573 - 6576
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine 1.) -70 -> 25 deg C, 2 h, THF, hexane; 2.) 0 deg C -> r.t., overnight; Yield given. Multistep reaction;
参考文献
Synthesis, , # 11 p. 1362 - 1364
反应条件
1: NH2OH*HCl; aq. NaOH / ethanol / 2 h / pH 8 / Heating 2: 90 percent / Ac2O / 2 h / Heating 3: 75 percent / POCl3 / 1 h / Heating 4: 75 percent / N2H4*H2O / 5 h / Heating View Scheme
参考文献
El-Sayed, Ola A.; Aboul-Enein, Hassan Y.
Archiv der Pharmazie, 2001 , vol. 334, # 4 p. 117 - 120
反应条件
1: POCl3 / Heating 2: 94 percent / hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 20 °C 3: thionyl chloride / benzene / 0.5 h / Heating View Scheme
参考文献
El-Sayed, Ola A.; Aboul-Enein, Hassan Y.
Archiv der Pharmazie, 2001 , vol. 334, # 4 p. 117 - 120
反应条件
1: NH2OH*HCl; aq. NaOH / ethanol / 2 h / pH 8 / Heating 2: 90 percent / Ac2O / 2 h / Heating View Scheme
参考文献
Raj, T. Tilak; Ambekar, Sarvottam Y.
Journal of Chemical Research, Miniprint, 1988 , # 2 p. 537 - 551
反应条件
1: 67 percent / acetic acid / 5 h / Heating 2: 72 percent / polyphosphoric acid / 8 h / 140 °C View Scheme
参考文献
Suresh; Dhanabal; Nandha Kumar; Mohan
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2375 - 2379
反应条件
sodium tetrahydroborate in methanol 3 h;
参考文献
Uchida; Tabusa; Komatsu; Morita; Kanbe; Nakagawa
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3775 - 3786
反应条件
1: POCl3 / Heating 2: 94 percent / hydroxylamine hydrochloride; sodium acetate / methanol / 0.33 h / 20 °C View Scheme
参考文献
Srivastava, Ambika; Singh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 9 p. 1868 - 1875
反应条件
sodium hydroxide; alkaline KMNO4 in water T=50 - 60°C; 0.5 h;
参考文献
Vijayalakshmi, S.; Rajendran, S. P.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994 , vol. 33, # 2 p. 159 - 162
反应条件
trichlorophosphate Heating;
参考文献
Srivastava, Ambika; Singh
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 9 p. 1868 - 1875
