炔丙基alpha-D-吡喃半乳糖苷合成路线 （共 6 条）
反应条件
sulfuric acid; silica gel
T=65°C; 6 h; Inert atmosphere;
参考文献
Krishnan, Baiju P.; Ramakrishnan, Shyama; Sureshan, Kana M.
Chemical Communications, 2013 , vol. 49, # 15 p. 1494 - 1496
反应条件
1.1: dichloromethane / 0.5 h / 0 °C
1.2: 5 h / 20 °C
2.1: sodium methylate; methanol / 2 h / pH 9
3.1: 1 h / 20 °C / |Molecular sieve; |Inert atmosphere
3.2: 2 h / -30 °C / |Molecular sieve; |Inert atmosphere
View Scheme
参考文献
Meng, Bo; Zhu, Zhenqian; Baker, David C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 28 p. 5182 - 5191
反应条件
1.1: sodium acetate / 24 h / 70 °C / |Inert atmosphere
2.1: dichloromethane / 0.5 h / 0 °C
2.2: 5 h / 20 °C
3.1: sodium methylate; methanol / 2 h / pH 9
4.1: 1 h / 20 °C / |Molecular sieve; |Inert atmosphere
4.2: 2 h / -30 °C / |Molecular sieve; |Inert atmosphere
View Scheme
参考文献
Meng, Bo; Zhu, Zhenqian; Baker, David C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 28 p. 5182 - 5191
反应条件
1: T=20°C; 1 h; Molecular sieveInert atmosphere;
2: With N-iodo-succinimide; trimethylsilyl trifluoromethanesulfonate
T=-30°C; 2 h; Molecular sieveInert atmosphere; Reagent/catalystSolvent; stereoselective reaction;
参考文献
Meng, Bo; Zhu, Zhenqian; Baker, David C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 28 p. 5182 - 5191
反应条件
aminosulfonic acid
T=80°C; Fischer glycosylation; 4 h; Neat (no solvent); optical yield given as percent de;
参考文献
Guchhait, Goutam; Misra, Anup Kumar
Catalysis Communications, 2011 , vol. 14, # 1 p. 52 - 57
反应条件
1.1: sodium methylate; methanol / 2 h / pH 9
2.1: 1 h / 20 °C / |Molecular sieve; |Inert atmosphere
2.2: 2 h / -30 °C / |Molecular sieve; |Inert atmosphere
View Scheme
参考文献
Meng, Bo; Zhu, Zhenqian; Baker, David C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 28 p. 5182 - 5191
