4-(3-异丙基-[1,2,4]噁二唑-5-基)哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
in 1,4-dioxane 18 h; Heating / reflux;
参考文献
PFIZER LIMITED
Patent: WO2006/114706 A1, 2006 ;
Location in patent: Page/Page column 34-35 ;
WO 2006/114706 A1
反应条件
1: N'-hydroxy-2-methylpropanimidamide With sodium hydride in tetrahydrofuran T=20 - 50°C; 3 h; Molecular sieve; 2: methyl N-tert-butoxycarbonyl-piperidine-4-carboxylate in tetrahydrofuran 3 h; Reflux;
参考文献
Journal of Medicinal Chemistry, , vol. 51, # 17 p. 5172 - 5175
反应条件
hydrogenchloride in 1,4-dioxane; dichloromethane T=40°C; 0.666667 h;
参考文献
PFIZER LIMITED
Patent: WO2006/114706 A1, 2006 ;
Location in patent: Page/Page column 35 ;
WO 2006/114706 A1
