5-甲基-3-氧代-2-苯基-2,3-二氢-1H-吡唑-4-羧酸苄酯合成路线 （共 3 条）
反应条件
1: 3-methyl-1-phenyl-3-pyrazolin-5-one With calcium hydroxide powder in 1,4-dioxane
T=50°C; 0.333333 h;
2: benzyl chloroformate in 1,4-dioxane
T=10 - 90°C; 3 h;
参考文献
Amgen Inc.
Patent: WO2006/116713 A1, 2006 ;
Location in patent: Page/Page column 116 ;
WO 2006/116713 A1
反应条件
1: 3-methyl-1-phenyl-3-pyrazolin-5-one With calcium hydroxide powder in 1,4-dioxane
T=50°C; 0.333333 h;
2: benzyl chloroformate in 1,4-dioxane
T=10 - 90°C; 3 h;
参考文献
AMGEN INC.
Patent: WO2008/86014 A2, 2008 ;
Location in patent: Page/Page column 55 ;
反应条件
trimethylaluminum in chlorobenzene; toluene
T=0 - 23°C; 48 h; Inert atmosphere; regioselective reaction;
参考文献
Siegmund, Aaron; Retz, Daniel; Xi, Ning; Dominguez, Celia; Buerli, Roland; Liu, Longbin
Synlett, 2008 , # 7 p. 1005 - 1008
