3-二甲基氨基甲基-5-甲基-2-己酮合成路线 （共 5 条）
反应条件
1: in methanol
16 h; Reflux;
2: With sodium hydroxide in methanol; water
pH=~ 8;
参考文献
AUSPEX PHARMACEUTICAL ,INC.; GANT, Thomas, G.; SHAHBAZ, Manoucherhr
Patent: WO2010/44981 A2, 2010 ;
Location in patent: Page/Page column 28 ;
反应条件
1: in acetonitrile
T=20°C;
2: With hydrogenchloride in water
3: With sodium hydroxide in water
参考文献
AUSPEX PHARMACEUTICAL, INC.; GANT, Thomas, G.; ZHANG, Chengzhi; SHAHBAZ, Manouchehr
Patent: WO2011/153157 A2, 2011 ;
Location in patent: Page/Page column 44 ;
WO 2011/153157 A2
反应条件
hydrogenchloride in ethanol
T=95°C; Mannich Aminomethylation;
参考文献
Liu, Chunyi; Chen, Zhengping; Li, Xiaomin; Tang, Jie; Qin, Xiaofeng
Chirality, 2013 , vol. 25, # 4 p. 215 - 223
反应条件
hydrogenchloride; potassium hydroxide
参考文献
Yu, Qian-Sheng; Luo, Weiming; Deschamps, Jeffery; Holloway, Harold W.; Kopajtic, Theresa; Katz, Jonathan L.; Brossi, Arnold; Greig, Nigel H.
ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 3 p. 105 - 109
反应条件
in ethanol
18 h; Reflux;
参考文献
Rhee, Sung-Whi; Ryan, Kenneth J.; Tanga, Mary J.
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 367 - 370
