6,7-二氢噻吩并[3,2-d]嘧啶-2,4-二醇合成路线 （共 5 条）
反应条件
hydrogenchloride; water T=20 - 150°C; 7.75 h; Microwave irradiation;
参考文献
Boehringer Ingelheim International GmbH
Patent: US2007/259846 A1, 2007 ;
Location in patent: Page/Page column 29-30; 31 ;
反应条件
1: With water; sodium hydroxide T=20 - 85°C; 2: With hydrogenchloride in water T=0°C; pH=0 - 1; Product distribution / selectivity;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2009/140127 A2, 2009 ;
Location in patent: Page/Page column 21-22 ;
WO 2009/140127 A2
反应条件
1: isopropyl alcohol; triethylamine; titanium tetrachloride / dichloromethane / 3 h / -10 °C 2: hydrogenchloride / methanol / |Inert atmosphere; |Reflux; |Large scale 3: sodium hydroxide; water / 3 h / 85 °C / |Large scale View Scheme
反应条件
1: hydrogenchloride / methanol / |Inert atmosphere; |Reflux; |Large scale 2: sodium hydroxide; water / 3 h / 85 °C / |Large scale View Scheme
反应条件
N,N-diethylaniline; trichlorophosphate T=80°C; 22 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2006/111549 A1, 2006 ;
Location in patent: Page/Page column 61; 59; 65; 68; 69; 72; 74; 76; 84 ;
