2-(2-羟基乙基)吗啉-4-羧酸叔丁酯合成路线 （共 5 条）
反应条件
triethylamine in dichloromethane T=20°C; 3 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; YEUNG, Kap-Sun; PARCELLA, Kyle, E.; BENDER, John, A.; BENO, Brett, R.; GRANT-YOUNG, Katharine, A.; HAN, Ying; HEWAWASAM, Piyasena; KADOW, John, F.; NICKEL, Andrew
Patent: WO2011/112191 A1, 2011 ;
Location in patent: Page/Page column 454-455 ;
WO 2011/112191 A1
反应条件
hydrogen; palladium 10 on activated carbon in methanol 8 h;
参考文献
WO2012/120476 A1, ;
Page/Page column 64 ;
WO 2012/120476 A1
反应条件
1: With borane-THF in tetrahydrofuran T=20°C; 12 h; 2: With methanol in tetrahydrofuran T=20°C;
参考文献
WO2008/70150 A1, ;
Page/Page column 61-62 ;
WO 2008/070150 A1
反应条件
1: palladium 10 on activated carbon; ammonium formate / ethanol / 3 h / 23 °C / Inert atmosphere 2: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 23 °C / Inert atmosphere 3: sodium hydroxide / diethyl ether; dichloromethane; water; ethyl acetate / 18 h / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6824 - 6831
反应条件
1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 23 °C / Inert atmosphere 2: sodium hydroxide / diethyl ether; dichloromethane; water; ethyl acetate / 18 h / Inert atmosphere View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 19 p. 6824 - 6831
