4-(2-二正丙基胺乙基)-1,3-二氯-2H-吲哚-2-酮合成路线 （共 19 条）
反应条件
1: With hydrogen; palladium 10 on activated carbon in water T=30 - 35°C; P=2942.29 Torr; 8 h; 2: With sodium hydroxide in water pH=10 - 11; 3: With hydrogenchloride in ethanol T=0 - 20°C; pH=2.0 - 3.0; 0.5 - 0.666667 h;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/84499 A1, 2008 ;
Location in patent: Page/Page column 8 ;
反应条件
hydrogen; palladium 10 on activated carbon in methanol T=20°C; P=3677.86 Torr; 24 h;
参考文献
Tarur, Venkatasubramanian Radhakrishna; Sathe, Dhananjay Govind; Mondkar, Harish Kashinath; Bhopalkar, Rajesh Ganpat; Patil, Samadhan Daulat
Patent: US2005/159605 A1, 2005 ;
Location in patent: Page/Page column 5 ;
反应条件
1: in water; acetonitrile T=65 - 70°C; 1.25 h; 2: With hydrogenchloride in water pH=2;
参考文献
TORRENT PHARMACEUTICALS LTD
Patent: WO2005/80333 A1, 2005 ;
Location in patent: Page/Page column 23 ;
反应条件
1: in water; toluene Inert atmosphereReflux; 2: With sodium tetrahydroborate in water; acetonitrile 3: With hydrogenchloride in dichloromethane; water; acetonitrile T=5°C; 1 h;
参考文献
WO2011/30330 A2, ;
Page/Page column 9 ;
反应条件
hydrogenchloride in water
参考文献
WO2005/40115 A1, ;
Page/Page column 6 ;
反应条件
1: With acetyl chloride in dichloromethane T=20°C; 0.5 h; 2: With anhydrous iron chloride in dichloromethane T=50°C; 2 h; Heating / reflux; 3: With hydrogenchloride; ammonia Product distribution / selectivity; more than 3 stages;
参考文献
Helm AG; CF Pharma Gyogyszergyarto Kft.
Patent: EP1568689 A1, 2005 ;
Location in patent: Page/Page column 7 ;
反应条件
hydrogenchloride in water Large scale;
参考文献
Hayler, John D.; Howie, Simon L. B.; Giles, Robert G.; Negus, Alan; Oxley, Paul W.; Walsgrove, Timothy C.; Whiter
Organic Process Research and Development, 1998 , vol. 2, # 1 p. 3 - 9
反应条件
hydrogenchloride in water Large scale;
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
反应条件
1.1: ethanol; sodium / tetrahydrofuran / 15 - 30 °C / Inert atmosphere 1.2: 25 - 30 °C 2.1: sodium hydroxide; water / toluene; methanol / 0 - 5 °C / pH 12 2.2: 15 °C 2.3: 25 - 70 °C / pH < 2 / Activated charcoal 3.1: hydrogen / 5 Pd(II)/C(eggshell) / methanol / 25 - 35 °C / 2059.6 - 3236.52 Torr / Sealed tube 3.2: 0 - 35 °C View Scheme
反应条件
1: palladium on activated charcoal; hydrazine hydrate 2: sodium hydroxide; water / |Large scale 3: pyridine / |Large scale 4: hydrogenchloride / water / |Large scale View Scheme
参考文献
Organic Process Research and Development, , vol. 2, # 1 p. 3 - 9
