2-甲基-3-硝基-N,N-二丙基苯乙酰胺合成路线 （共 11 条）
反应条件
hydrogenchloride; thionyl chloride; sodium carbonate in water; toluene
反应条件
sodium carbonate in water; toluene T=10 - 20°C; 1.5 h; Yield given;
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 6 p. 939 - 947
反应条件
1: SOCl2 2: Na2CO3 / toluene; H2O / 1.5 h / 10 - 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 29, # 6 p. 939 - 947
反应条件
1: 100 percent / BH3 / tetrahydrofuran 2: 100 percent / SOCl2, pyridine 3: 99 percent / ethanol; H2O 4: 97 percent / H2SO4, HOAc / H2O 5: SOCl2 6: Na2CO3 / toluene; H2O / 1.) 10 deg C, 0.5 h, 2.) RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 100 percent / SOCl2, pyridine 2: 99 percent / ethanol; H2O 3: 97 percent / H2SO4, HOAc / H2O 4: SOCl2 5: Na2CO3 / toluene; H2O / 1.) 10 deg C, 0.5 h, 2.) RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 97 percent / H2SO4, HOAc / H2O 2: SOCl2 3: Na2CO3 / toluene; H2O / 1.) 10 deg C, 0.5 h, 2.) RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 99 percent / ethanol; H2O 2: 97 percent / H2SO4, HOAc / H2O 3: SOCl2 4: Na2CO3 / toluene; H2O / 1.) 10 deg C, 0.5 h, 2.) RT, 1 h View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 83 percent / BH3 / tetrahydrofuran / 1.) reflux, 1h, 2.) overnight 2: 1.) K, EtOH / 1.) Et2O, 10 min, 2.) Et2O, overnight 3: 80 percent / 2percent aq. NaOH, 30percent aq. H2O2 / 1 h / Ambient temperature 4: 78 percent / H2 / 5percent Pd/C / ethanol / 5 h / 2585.7 Torr / Ambient temperature View Scheme
参考文献
Matera, Carlo; Quadri, Marta; Pelucchi, Silvia; De Amici, Marco; Dallanoce, Clelia
Monatshefte fur Chemie, 2014 , vol. 145, # 7 p. 1139 - 1144
反应条件
tetrahydrofuran; borane 1 h; Heating;
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
1: 83 percent / BH3 / tetrahydrofuran / 1.) reflux, 1h, 2.) overnight 2: 1.) K, EtOH / 1.) Et2O, 10 min, 2.) Et2O, overnight 3: 80 percent / 2percent aq. NaOH, 30percent aq. H2O2 / 1 h / Ambient temperature View Scheme
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
