2-[2-(二丙基氨基)乙基]-6-硝基苯基丙酮酸乙酯合成路线 (共 3 条)
反应条件
1: oxalic acid diethyl ester With ethanol; sodium in tetrahydrofuran T=15 - 30°C; Inert atmosphere; 2: N-[2-(2-methyl-3-nitrophenyl)ethyl]-N-propylpropan-1-amine hydrochloride in tetrahydrofuran T=25 - 30°C;
参考文献
WO2011/72704 A1, ;
Page/Page column 6-7 ;
反应条件
1: oxalic acid diethyl ester With sodium ethanolate in tetrahydrofuran; ethanol 0.25 h; 2: 1-(2-dipropylaminoethyl)-2-methyl-3-nitrobenzene in tetrahydrofuran; ethanol T=20 - 30°C; 20 - 24 h; 3: With hydrogenchloride in water; ethyl acetate pH=7.5 - 8.0; Product distribution / selectivity;
参考文献
WO2006/123356 A1, ;
Page/Page column 25 ;
反应条件
1: With water; sodium hydroxide in methanol; toluene T=0 - 5°C; pH=12; 2: With dihydrogen peroxide in methanol; water; toluene T=15°C; 3: With hydrogenchloride in methanol; water; toluene T=25 - 70°C; pH=< 2; Activated charcoal;
参考文献
PHARMATHEN S.A.; KOFTIS, Theoharis, V.; GEORGOPOULOU, Ioanna; SONI, Rohit, Ravikant; MANDALOU, Panagiota; ALEXANDRAKI, Elli
Patent: WO2011/72704 A1, 2011 ;
Location in patent: Page/Page column 6-7 ;