2-[2-(二丙基氨基)乙基]-6-硝基苯乙酸盐酸盐合成路线 （共 13 条）
反应条件
1.1: ethanol; sodium / tetrahydrofuran / 15 - 30 °C / Inert atmosphere 1.2: 25 - 30 °C 2.1: sodium hydroxide; water / toluene; methanol / 0 - 5 °C / pH 12 2.2: 15 °C 2.3: 25 - 70 °C / pH < 2 / Activated charcoal View Scheme
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2585.7 Torr; 5 h; Ambient temperature;
参考文献
Gallagher, Gregory; Lavanchy, Patricia G.; Wilson, James W.; Hieble, J. Paul; DeMarinis, Robert M.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1533 - 1536
反应条件
1: With hydrogen; palladium 10 on activated carbon in water T=30 - 35°C; P=2942.29 Torr; 8 h; 2: With sodium hydroxide in water pH=10 - 11; 3: With hydrogenchloride in ethanol T=0 - 20°C; pH=2.0 - 3.0; 0.5 - 0.666667 h;
参考文献
IND-SWIFT LABORATORIES LIMITED
Patent: WO2008/84499 A1, 2008 ;
Location in patent: Page/Page column 8 ;
