反应条件
1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; acetonitrile / 0.5 h / 50 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 50 °C
3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 1 h / 0 °C
3.2: 0 - 25 °C
4.1: sodium hydroxide / 1,4-dioxane; water / 2 h / 25 °C
View Scheme
参考文献
Nakamura, Tsuyoshi; Asano, Masayoshi; Sekiguchi, Yukiko; Mizuno, Yumiko; Tamaki, Kazuhiko; Nara, Futoshi; Kawase, Yumi; Yabe, Yoshiyuki; Nakai, Daisuke; Kamiyama, Emi; Urasaki-Kaneno, Yoko; Shimozato, Takaichi; Doi-Komuro, Hiromi; Kagari, Takashi; Tomisato, Wataru; Inoue, Ryotaku; Nagasaki, Miyuki; Yuita, Hiroshi; Oguchi-Oshima, Keiko; Kaneko, Reina; Nishi, Takahide
European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 92 - 98