1-(4-硝基苯基)环戊烷甲腈合成路线 （共 4 条）
反应条件
sodium hydride in diethyl ether; dimethyl sulfoxide T=20 - 30°C; 24 h;
参考文献
ADDEX PHARMA SA
Patent: WO2008/117175 A2, 2008 ;
Location in patent: Page/Page column 99 ;
WO 2008/117175 A2
参考文献
WO2003/99276 A1, ;
Page 233, 235 ;
WO 03/099276 A1
反应条件
hydrogen; palladium on activated charcoal
参考文献
Trivedi, Bharat K.; Purchase, Terri Stoeber; Holmes, Ann; Augelli-Szafran, Corinne E.; Essenburg, Arnold D.; et al.
Journal of Medicinal Chemistry, 1994 , vol. 37, # 11 p. 1652 - 1659
反应条件
sulfuric acid
T=100°C; 2 h;
参考文献
Illig, Carl R.; Ballentine, Shelley K.; Chen, Jinsheng; DesJarlais, Renee Louise; Meegalla, Sanath K.; Wall, Mark; Wilson, Kenneth
Patent: US2007/249608 A1, 2007 ;
Location in patent: Page/Page column 33 ;
US 20070249608 A1
