4-乙炔-3-甲氧基苯甲腈合成路线 （共 3 条）
反应条件
sodium hydride in toluene
Heating;
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
反应条件
1: 86 percent / Et3N / CuI; PdCl2(PPh3)2 / 60 °C
2: 67 percent / sodium hydride / toluene / Heating
View Scheme
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
反应条件
1: 89 percent / Et3N / CH2Cl2 / cooling
2: 86 percent / Et3N / CuI; PdCl2(PPh3)2 / 60 °C
3: 67 percent / sodium hydride / toluene / Heating
View Scheme
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
