2-氯-5-氰基苯甲酸甲酯合成路线 （共 4 条）
反应条件
pyrrolidine; potassium tert-butylate; sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=10°C; 0.25 h;
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
反应条件
sodium hydroxide in methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Wagenen, Bradford Van; Stormann, Thomas M.; Moe, Scott T.; Sheehan, Susan M.; McLeod, Donald A.; Smith, Daryl L.; Isaac, Methvin Benjamin; Slassi, Abdelmalik
Patent: US2003/55085 A1, 2003 ;
US 20030055085 A1
反应条件
dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine in dichloromethane
T=0 - 25°C;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Patent: EP1719767 A1, 2006 ;
Location in patent: Page/Page column 24-28; 41 ;
反应条件
1.1: NaNO2; aq. HCl
1.2: KCN
2.1: 94 percent / 1,3-dicyclohexylcarbodiimide / 4-dimethylaminopyridine / CH2Cl2 / 0 - 25 °C
View Scheme
参考文献
Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485
