1-叔丁氧羰基-4-哌啶甲酰胺合成路线 （共 17 条）
反应条件
4-methylmorpholine N-oxide in 1,4-dioxane Product distribution / selectivity;
参考文献
Metabolex, Inc.
Patent: US2011/318418 A1, 2011 ;
Location in patent: Page/Page column 11 ;
反应条件
ammonia; chloroformic acid ethyl ester; triethylamine 1.) chloroform, 0 deg C, 8 min; 2.) chloroform, RT, 2-4 h; Yield given. Multistep reaction;
参考文献
European Journal of Medicinal Chemistry, , vol. 19, # 2 p. 181 - 186
反应条件
methanol; (ethylenediamine)Pd(NO3)2 T=60°C; Inert atmosphere;
参考文献
Tambara, Koujiro; Pantos, G. Dan
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 15 p. 2466 - 2472
反应条件
1.1: Et3N 2.1: aq. NaOH 3.1: ClCOO-i-Bu; N-methylmorpholine 3.2: aq. NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
1.1: Et3N 2.1: aq. NaOH 3.1: ClCOO-i-Bu; N-methylmorpholine 3.2: aq. NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
1.1: aq. NaOH 2.1: ClCOO-i-Bu; N-methylmorpholine 2.2: aq. NH3 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 5 p. 757 - 761
反应条件
1: 7.37 g / TFAA / CH2Cl2; pyridine / 2 h / 20 °C 2: TFA / 20 °C View Scheme
参考文献
G.D. SEARLE and CO.
Patent: EP1221441 A2, 2002 ;
Location in patent: Page 185 - 186 ;
反应条件
1: 7.37 g / TFAA / CH2Cl2; pyridine / 2 h / 20 °C 2: 43 percent / diethyl ether; tetrahydrofuran / 11 h / 20 °C 3: TFA / 20 °C View Scheme
参考文献
Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829
反应条件
hydrogenchloride in ethyl acetate
参考文献
Itani, Hiromichi; Ito, Harunobu; Sakata, Yoshihiko; Hatakeyama, Yoshifumi; Oohashi, Hiroko; Satoh, Yoshinari
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 5 p. 757 - 761
反应条件
1: With triethylamine; trichlorophosphate in dichloromethane T=0 - 20°C; 2: With sodium hydrogencarbonate in dichloromethane
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2004/2483 A1, 2004 ;
Location in patent: Page/Page column 21-22; 39-40 ;
WO 2004/002483 A1
