1-叔丁氧羰基-4-哌啶甲酰胺合成路线 （共 17 条）
反应条件
1: With triethyloxonium tetra-fluoroborate in dichloromethane T=20°C; 4 h; 2: With methanol; ammonia pH=10;
参考文献
Asinex Limited; KAZULKIN, Denis Nikolaevich; KOCHUBEY, Valeriy Sergeevich
Patent: EP2719696 A1, 2014 ;
Location in patent: Paragraph 0217; 0218 ;
反应条件
1.1: Lawesson's reagent / dichloromethane; ethylene glycol dimethyl ether / 20 °C 2.1: hydrogenchloride / 1,4-dioxane / 3 h 2.2: 2 h / 20 °C View Scheme
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; Pulici, Maurizio; Traquandi, Gabriella; Marchionni, Chiara; Scolaro, Alessandra; Colombo, Nicoletta
Patent: US2013/324551 A1, 2013 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=-78 - 20°C; 0.5 h;
参考文献
Agouron Pharmaceuticals, Inc.
Patent: EP1215208 A2, 2002 ;
Location in patent: Example J(4) ;
EP 1215208 A2
反应条件
Lawesson's reagent in ethylene glycol dimethyl ether; dichloromethane T=20°C;
参考文献
NERVIANO MEDICAL SCIENCES S.R.L.; Pulici, Maurizio; Traquandi, Gabriella; Marchionni, Chiara; Scolaro, Alessandra; Colombo, Nicoletta
Patent: US2013/324551 A1, 2013 ;
Location in patent: Paragraph 0311; 0312; 0313 ;
反应条件
in 1,4-dioxane; hexane
参考文献
Merck and Co., Inc.
Patent: US6248755 B1, 2001 ;
US 6248755 B1
反应条件
1: 7.37 g / TFAA / CH2Cl2; pyridine / 2 h / 20 °C 2: 43 percent / diethyl ether; tetrahydrofuran / 11 h / 20 °C View Scheme
参考文献
Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829
反应条件
1: POCl3 / pyridine
2: 60 percent / NaN3, NH4Cl / dimethylformamide / 100 °C
3: 85 percent / HCO2H, HCl / 0.25 h / Ambient temperature
View Scheme
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
