N-Boc-4-氰基哌啶合成路线

参考文献

Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532

541-41-3氯甲酸乙酯+

91419-52-2N-Boc-4-氰基哌啶

1016258-66-41-叔丁基4-乙基4-氰基哌啶-1,4-二羧酸

参考文献

Giordanetto, Fabrizio; Wallberg, Andreas; Knerr, Laurent; Selmi, Nidhal; Ullah, Victoria; Thorstensson, Fredrik; Lindelo, Asa; Karlsson, Staffan; Nikitidis, Grigorios; Llinas, Antonio; Wang, Qing-Dong; Lindqvist, Anders; Hoegberg, Agot; Lindhardt, Emma; Astrand, Annika; Duker, Goeran
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 1 p. 119 - 124

91419-52-2N-Boc-4-氰基哌啶

362703-34-2N-Boc-4-氰基哌啶-4-甲酸甲酯

参考文献

Woo, Hyun Min; Lee, Yun Suk; Roh, Eun Joo; Seo, Seon Hee; Song, Chi Man; Chung, Hye Jin; Pae, Ae Nim; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5910 - 5915

91419-52-2N-Boc-4-氰基哌啶

1016258-69-71-叔丁基 4-乙基 4-(氨基甲基)哌啶-1,4-二羧酸

参考文献

Woo, Hyun Min; Lee, Yun Suk; Roh, Eun Joo; Seo, Seon Hee; Song, Chi Man; Chung, Hye Jin; Pae, Ae Nim; Shin, Kye Jung
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 19 p. 5910 - 5915

91419-52-2N-Boc-4-氰基哌啶

144222-22-01-叔丁氧羰基-4-氨甲基哌啶

参考文献

ACTELION PHARMACEUTICALS LTD
Patent: WO2004/2483 A1, 2004 ;
Location in patent: Page/Page column 21-22 ;
WO 2004/002483 A1

75-16-1甲基溴化镁+

91419-52-2N-Boc-4-氰基哌啶

206989-61-94-乙酰基哌啶-1-甲酸叔丁酯

参考文献

ASTRAZENECA AB
Patent: WO2004/99178 A1, 2004 ;
Location in patent: Page 39 ;
WO 2004/099178 A1

917-64-6magnesium,carbanide,iodide+

91419-52-2N-Boc-4-氰基哌啶

206989-61-94-乙酰基哌啶-1-甲酸叔丁酯

参考文献

Iyobe; Uchida; Kamata; Hotel; Kusama; Harada
Chemical and Pharmaceutical Bulletin, 2001 , vol. 49, # 7 p. 822 - 829

91419-52-2N-Boc-4-氰基哌啶

767263-33-24-(吡啶-2-基)哌啶-4-甲腈

参考文献

Kuduk, Scott D.; Chang, Ronald K.; Di Marco, Christina N.; Pitts, Daniel R.; Greshock, Thomas J.; Ma, Lei; Wittmann, Marion; Seager, Matthew A.; Koeplinger, Kenneth A.; Thompson, Charles D.; Hartman, George D.; Bilodeau, Mark T.; Ray, William J.
Journal of Medicinal Chemistry, 2011 , vol. 54, # 13 p. 4773 - 4780

1435-49-01,2-二氯-4-氟苯+

91419-52-2N-Boc-4-氰基哌啶

669068-10-41-N-Boc-4-(3,4-二氯苯基)-4-氰基哌啶

参考文献

ABBVIE INC.; BAYBURT, Erol K.; CLAPHAM, Bruce; COX, Phil B.; DAANEN, Jerome F.; GOMTSYAN, Arthur; KORT, Michael E.; KYM, Philip R.; VOIGHT, Eric A.; SCHMIDT, Robert G.; DART, Michael J.; GFESSER, Gregory
Patent: WO2013/62966 A2, 2013 ;
Location in patent: Paragraph 254; 255 ;

106-38-7对溴甲苯+

91419-52-2N-Boc-4-氰基哌啶

912768-78-64-(4-甲基苯甲酰基)哌啶-1-羧酸叔丁酯

参考文献

Orjales, Aurelio; Mosquera, Ramon; Toledo, Antonio; Pumar, M. Carmen; Garcia, Neftali; Cortizo, Lourdes; Labeaga, Luis; Innerarity, Ana
Journal of Medicinal Chemistry, 2003 , vol. 46, # 25 p. 5512 - 5532