4-(1H-四氮唑-5-基)哌啶盐酸盐合成路线 （共 4 条）
反应条件
hydrogenchloride; formic acid
0.25 h; Ambient temperature;
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
反应条件
1: 60 percent / NaN3, NH4Cl / dimethylformamide / 100 °C
2: 85 percent / HCO2H, HCl / 0.25 h / Ambient temperature
View Scheme
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
反应条件
1: 1.) Et3N, ClCO2C2H5; 2.) NH3 / 1.) chloroform, 0 deg C, 8 min; 2.) chloroform, RT, 2-4 h
2: POCl3 / pyridine
3: 60 percent / NaN3, NH4Cl / dimethylformamide / 100 °C
4: 85 percent / HCO2H, HCl / 0.25 h / Ambient temperature
View Scheme
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
反应条件
1: POCl3 / pyridine
2: 60 percent / NaN3, NH4Cl / dimethylformamide / 100 °C
3: 85 percent / HCO2H, HCl / 0.25 h / Ambient temperature
View Scheme
参考文献
Schlewer; Wermuth; Chambon
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 181 - 186
