1: ethyl 3-(4-cyanophenyl)3-oxopropanoate With (hydroxy(tosyloxy)iodo)benzene in acetonitrile T=20 - 80°C; 2.33333 h; 2: thiourea in acetonitrile T=80°C; 16 h;

1.1: 4-(N,N-dimethlyamino)pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.24 h / 25 °C 2.1: ethanol / 0.2 h / |Reflux 3.1: hydroxy-tosyloxyiodobenzene / acetonitrile / 0.02 h / 0.8 - 25 °C 3.2: 16 h / 80 °C View Scheme

1.1: [(t-Bu)3PH]BF4; N,N-dicyclohexylmethylamine; n-butyronitrile; dichloro(cycloocta-1,5-diene)palladium(II); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; magnesium chloride / 1,4-dioxane / 18 h / 80 °C / |Inert atmosphere; |Glovebox 2.1: (hydroxy(tosyloxy)iodo)benzene / acetonitrile / 2.33 h / 20 - 80 °C 2.2: 16 h / 80 °C View Scheme