2-(4-氨基-2-氟苯基)乙酸合成路线 （共 4 条）
反应条件
palladium on activated charcoal; hydrogen in ethanol
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde
Patent: WO2013/29338 A1, 2013 ;
Location in patent: Page/Page column 127 ;
WO 2013/029338 A1
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 20 °C / |Inert atmosphere
1.2: 0 - 20 °C
2.1: acetic acid; sulfuric acid / water / 100 °C
3.1: palladium on activated charcoal; hydrogen / ethanol
View Scheme
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde
Patent: WO2013/29338 A1, 2013 ;
WO 2013/029338 A1
反应条件
1: acetic acid; sulfuric acid / water / 100 °C
2: palladium on activated charcoal; hydrogen / ethanol
View Scheme
参考文献
GLAXO GROUP LIMITED; WANG, Yonghui; CAI, Wei; LIU, Qian; MENG, Qinghua; CHENG, Yaobang; YANG, Ting; ZHANG, Guifeng; XIANG, Jianing; WU, Chengde
Patent: WO2013/29338 A1, 2013 ;
WO 2013/029338 A1
反应条件
1: With thionyl chloride
T=0 - 40°C; 48 h;
2: With sodium hydrogencarbonate in dichloromethane; water
Product distribution / selectivity;
参考文献
GLAXO GROUP LIMITED
Patent: WO2007/88190 A1, 2007 ;
Location in patent: Page/Page column 58 ;
