1-(氨基甲基)环丙烷羧酸甲酯合成路线 （共 4 条）
反应条件
1: 80 percent / Et3N / acetonitrile / 2 h / 0 °C 2: 48 percent / LiOH / methanol; H2O / 72 h / Ambient temperature View Scheme
参考文献
Helvetica Chimica Acta, , vol. 81, # 12 p. 2218 - 2243
反应条件
ammonia; hydrogen; 5 Rh/Al2O3 in ethanol
T=20°C; 72 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2009/67547 A1, 2009 ;
Location in patent: Page/Page column 268; 269 ;
WO 2009/067547 A1
反应条件
1: With ammonium acetate in methanol
T=60°C; 2.5 h;
2: With sodium cyanoborohydride in methanol
T=0 - 20°C;
3: With ammonium hydroxide; water in methanol
参考文献
Myriad Genetics, Incorporated
Patent: US2009/275583 A1, 2009 ;
Location in patent: Page/Page column 32 ;
反应条件
1: DCC, DMAP
2: H2 / Raney-Ni / methanol / 4 h / 750.06 Torr / Ambient temperature
View Scheme
参考文献
Seebach, Dieter; Abele, Stefan; Sifferlen, Thierry; Haenggi, Martin; Gruner, Sibylle; Seiler, Paul
Helvetica Chimica Acta, 1998 , vol. 81, # 12 p. 2218 - 2243
