n-butyllithium in tetrahydrofuran; hexane T=-25°C; Ring cleavage; 0.5 h;

n-butyllithium in tetrahydrofuran; hexane T=-25°C; Ring cleavage; 0.5 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1732799', constants.ctx, '0')">carbon tetrabromide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '610776', constants.ctx, '0')">triphenylphosphine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=0&deg;C;&nbsp;Bromination;&nbsp;<br /> &nbsp;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '8128145', constants.ctx, '0')">lithium bromide</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635680', constants.ctx, '0')">acetone</a> <br />1.5&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 89 percent / 3 Angstroem sieves; 3 M t-butylhydroperoxide; (+)-diethyl tartrate / titanium(IV) isopropoxide / 2,2,4-trimethyl-pentane; CH₂Cl₂ / 0.75 h / -25 &deg;C<br />2: 84 percent / CBr₄; triphenylphosphine / CH₂Cl₂ / 0 &deg;C<br /> <br /> &nbsp;