2-(4-甲氧苯基)噻唑-5-甲醛合成路线 （共 4 条）
反应条件
1: 2-(4-methoxyphenyl)-1,3-thiazole With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=0°C; 3: With acetic acid in tetrahydrofuran; hexane
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
Location in patent: Page/Page column 69 ;
反应条件
1.1: sodium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 3 h / 100 °C 2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C 2.2: 0 °C View Scheme
反应条件
1: 2-(4-methoxyphenyl)-1,3-thiazole With n-butyllithium in tetrahydrofuran; hexane
T=-78°C;
2: N,N-dimethyl-formamide in tetrahydrofuran; hexane
T=0°C;
3: With acetic acid in tetrahydrofuran; hexane
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
Location in patent: Page/Page column 69 ;
反应条件
1.1: sodium carbonate / triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide; water / 3 h / 100 °C
2.1: n-butyllithium / hexane; tetrahydrofuran / -78 °C
2.2: 0 °C
View Scheme
参考文献
Daiichi Sankyo Company, Limited
Patent: EP2308838 A1, 2011 ;
