1: 6-bromo-7-methoxyquinazolin-2-amine With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0°C; 1 h; Inert atmosphere; 2: 2-iodo-propane in N,N-dimethyl-formamide; mineral oil T=60°C; 3.5 h;

triethylamine in tetrahydrofuran T=20°C; Product distribution / selectivity;

sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,4-dioxane; water 2 h; Heating / reflux;