1: 7-benzyloxy-6-bromo-2-aminoquinazoline With sodium hydride in N,N-dimethyl-formamide T=5°C; 0.5 h; 2: 2-iodo-propane in N,N-dimethyl-formamide T=60°C; 1.5 h; 3: 2-iodo-propane With sodium hydride Product distribution / selectivity; more than 3 stages;

triethylamine in tetrahydrofuran T=20°C; Product distribution / selectivity;