1H-1-乙基坎地沙坦西来替昔酯合成路线 （共 3 条）
反应条件
hydrogenchloride; water in acetone T=75°C; 6 h; Heating;
参考文献
Havllcek, Jaroslav; Mandelova, Zuzana; Weisemann, Ruediger; Strelec, Ivo; Placek, Lukas; Radl, Stanislav
Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 2 p. 347 - 362
反应条件
1: 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester With potassium carbonate in acetone
T=20°C; 1 h; Inert atmosphere;
2: ethyl iodide in acetone
T=20°C; 24 h;
参考文献
Havllcek, Jaroslav; Mandelova, Zuzana; Weisemann, Ruediger; Strelec, Ivo; Placek, Lukas; Radl, Stanislav
Collection of Czechoslovak Chemical Communications, 2009 , vol. 74, # 2 p. 347 - 362
反应条件
T=55°C; 336 h; Product distribution / selectivity;
参考文献
TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.
Patent: WO2006/122254 A2, 2006 ;
Location in patent: Page/Page column 12; 13 ;
