4-溴-1-异丙氧基-2-(三氟甲基)苯合成路线 （共 2 条）
反应条件
1: isopropyl alcohol With potassium tert-butylate in tetrahydrofuran
T=50°C; 0.166667 h; Inert atmosphere;
2: 5-bromo-2-fluoro-trifluoromethylbenzene in tetrahydrofuran
T=50°C;
参考文献
GLAXO GROUP LIMITED; LIN, Xichen; REN, Feng; ZHANG, Haibo
Patent: WO2011/113309 A1, 2011 ;
Location in patent: Page/Page column 26 ;
WO 2011/113309 A1
反应条件
1.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 20 °C / Cooling with ice; Inert atmosphere
2.1: potassium tert-butylate / tetrahydrofuran / 0.17 h / 50 °C / Inert atmosphere
2.2: 50 °C
View Scheme
参考文献
GLAXO GROUP LIMITED; LIN, Xichen; REN, Feng; ZHANG, Haibo
Patent: WO2011/113309 A1, 2011 ;
WO 2011/113309 A1
