3-溴-5-(三氟甲氧基)苯胺合成路线 （共 3 条）
反应条件
bis-triphenylphosphine-palladium(II) chloride; dihydroxyborane; sodium carbonate in ethylene glycol dimethyl ether T=120°C; Suzuki coupling; P=12001.2 Torr; 1 h; Microwave irradiation;
参考文献
Calderon, Felix; Vidal-Mas, Jaume; Burrows, Jeremy; De La Rosa, Juan Carlos; Jimenez-Diaz, Maria Belen; Mulet, Teresa; Prats, Sara; Solana, Jorge; Witty, Michael; Gamo, Francisco Javier; Fernandez, Esther
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 5 p. 373 - 377
反应条件
hydroxylamine hydrochloride; sodium acetate in methanol
T=20°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
Patent: WO2009/3999 A2, 2009 ;
Location in patent: Page/Page column 90 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium carbonate in ethylene glycol dimethyl ether
T=120°C; Suzuki coupling; P=12001.2 Torr; 1 h; Microwave irradiation;
参考文献
Calderon, Felix; Vidal-Mas, Jaume; Burrows, Jeremy; De La Rosa, Juan Carlos; Jimenez-Diaz, Maria Belen; Mulet, Teresa; Prats, Sara; Solana, Jorge; Witty, Michael; Gamo, Francisco Javier; Fernandez, Esther
ACS Medicinal Chemistry Letters, 2012 , vol. 3, # 5 p. 373 - 377
