1.1: CH2Cl2 / 2 h / 0 - 25 °C 1.2: 90 percent / potassium carbonate / methanol; H2O / 18 h / 0 - 25 °C 2.1: 69 percent / sodium hydroxide; tert-butyl hypochlorite; potassium osmate / ethyldiisopropylamine / propan-1-ol; H2O / 3 h / 25 °C 3.1: NaOH / methanol; H2O / 25 °C 3.2: 78 percent / 3 h / 90 °C View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1.1: ZnCl₂ / tetrahydrofuran / 18 h / 55 &deg;C<br />1.2: 68 percent / tetrahydrofuran / -78 - 25 &deg;C<br />2.1: 44 percent / Ti(O-iPr)4; (+)-diisopropyl tartrate; tert-butyl hydroperoxide / molecular sieves 4 Angstroem / CH₂Cl₂ / 14 h / -20 &deg;C<br /> <br /> &nbsp;