3-甲氧基-4-[(四氢-2H-吡喃-2-基)氧基]苯甲醛合成路线 （共 10 条）
反应条件
cerium(IV) sulfate quaternery hydrate in methanol T=130°C; 0.333333 h; Microwave irradiation; Temperature;
参考文献
Gonzalez-Calderon, Davir; Gonzalez-Gonzalez, Carlos A.; Fuentes-Benitez, Aydee; Cuevas-Yanez, Erick; Corona-Becerril, David; Gonzalez-Romero, Carlos
Tetrahedron Letters, 2013 , vol. 54, # 52 p. 7164 - 7166
反应条件
1: 1b) 60percent aq.NaOH, 2) aq.benzyltriethylammonium chloride / 1a) 0 deg C, 15 min, 1b) benzene, 18-20 deg C, few minutes, 2) benzene, 50 deg C, 10 h 2: 64 percent / 5 h / 240 °C View Scheme
参考文献
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 26, # 1-12 p. 1018 - 1020
反应条件
1: 1.) t-BuOK / 1.) DMSO, 30 min, 2.) 2 h, 25 deg C 2: aq. HCl / tetrahydrofuran / 0.67 h 3: 1.) 4-dimethylaminopyridine, 2.) 88percent aq. HCOOH / 1.) THF, 1 h, 25 deg C, 2.) 30 min 4: 1.) DMF, 2 h, 25 deg C, 2.) ether, 16 h, 5 deg C 5: KOH / methanol / 1 h / 25 °C View Scheme
参考文献
Webb, Thomas R.
Synthesis, 1984 , # 3 p. 213 - 214
反应条件
pyridinium p-toluenesulfonate in tetrahydrofuran
参考文献
Kim, Darrick S. H. L.
Patent: US6887898 B1, 2005 ;
Location in patent: Page/Page column 19; sheet 4 ;
反应条件
pyridinium p-toluenesulfonate in dichloromethane
T=20°C;
参考文献
Liang, Guang; Yang, Shulin; Zhou, Huiping; Shao, Lili; Huang, Kexin; Xiao, Jian; Huang, Zhifeng; Li, Xiaokun
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 2 p. 915 - 919
反应条件
1: sodium hydroxide / methanol / 3 h / 20 °C
2: hydrogenchloride / 4 h / 20 °C
View Scheme
参考文献
Leow, Pay-Chin; Bahety, Priti; Boon, Choon Pei; Lee, Chong Yew; Tan, Kheng Lin; Yang, Tianming; Ee, Pui-Lai Rachel
European Journal of Medicinal Chemistry, 2014 , vol. 71, p. 67 - 80
反应条件
sodium tetrahydroborate in tetrahydrofuran
参考文献
Kim, Darrick S. H. L.
Patent: US6887898 B1, 2005 ;
Location in patent: Page/Page column 22; sheet 7 ;
反应条件
1: 1.) t-BuOK / 1.) DMSO, 30 min, 2.) 2 h, 25 deg C
2: aq. HCl / tetrahydrofuran / 0.67 h
View Scheme
参考文献
Webb, Thomas R.
Synthesis, 1984 , # 3 p. 213 - 214
反应条件
1: 40 percent / piperidine, aniline / pyridine / 15 h / 70 - 80 °C
2: DCC / pyridine / 50 - 55 °C
3: 1M HCl / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Bernards; Lewis
Phytochemistry, 1992 , vol. 31, # 10 p. 3409 - 3412
反应条件
1: 40 percent / piperidine, aniline / pyridine / 15 h / 70 - 80 °C
2: DCC / pyridine
3: 1M HCl / tetrahydrofuran / 1 h / Ambient temperature
View Scheme
参考文献
Bernards; Lewis
Phytochemistry, 1992 , vol. 31, # 10 p. 3409 - 3412
