1-甲基-4-硝基-1H-吲哚合成路线 （共 10 条）
反应条件
sodium hydride in N,N-dimethyl-formamide 2 h; cooling;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
反应条件
potassium carbonate in n-heptane; ethyl acetate; N,N-dimethyl-formamide
参考文献
Hoffmann-La Roche Inc.
Patent: US6326501 B1, 2001 ;
参考文献
Hoffmann-La Roche Inc.
Patent: US6326501 B1, 2001 ;
反应条件
potassium ethanolate in N,N-dimethyl-formamide Heating;
参考文献
Bergman, Jan; Sand, Peter
Tetrahedron Letters, 1984 , vol. 25, # 18 p. 1957 - 1960
反应条件
potassium ethanolate in N,N-dimethyl-formamide Heating;
参考文献
Bergman, Jan; Norrby, Per-Ola; Sand, Peter
Tetrahedron, 1990 , vol. 46, # 17 p. 6113 - 6124
反应条件
potassium carbonate in N,N-dimethyl-formamide 2 h; Green chemistry;
参考文献
Jiang, Xinglong; Tiwari, Ashish; Thompson, Maethonia; Chen, Zhihong; Cleary, Thomas P.; Lee, Thomas B. K.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 604 - 608
反应条件
1.1: 79.23 percent / p-toluenesulfonic acid / 120 °C 2.1: diethyl oxalate; KOEt / dimethylsulfoxide; dimethylformamide / 24 h / 40 °C 3.1: KOH / acetone / 0 °C 3.2: 85.14 percent / acetone / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3417 - 3427
反应条件
1.1: diethyl oxalate; KOEt / dimethylsulfoxide; dimethylformamide / 24 h / 40 °C 2.1: KOH / acetone / 0 °C 2.2: 85.14 percent / acetone / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3417 - 3427
反应条件
potassium ethanolate in N,N-dimethyl-formamide 1 h; Heating;
参考文献
Tetrahedron, , vol. 46, # 17 p. 6085 - 6112
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C;
参考文献
Ple, Patrick A.; Green, Tim P.; Hennequin, Laurent F.; Curwen, Jon; Fennell, Michael; Allen, Jack; Lambert-Van Der Brempt, Christine; Costello, Gerard
Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 871 - 887
