2-苯基-7H-吡咯并[2,3-d]嘧啶-4-醇合成路线 (共 2 条)
反应条件
1: benzenecarboximidamide hydrochloride With sodium methylate in ethanol
T=20°C; 5 h;
2: 2-cyano-4,4-diethoxy-butyric acid ethyl ester in ethanol
5 h; Heating / reflux;
3: With acetic acid in ethanol; water
T=0°C; pH=7;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 31 ;
反应条件
trichlorophosphate
5 h; Heating / reflux;
参考文献
TIBOTEC PHARMACEUTICALS LTD.
Patent: WO2006/35061 A1, 2006 ;
Location in patent: Page/Page column 31; 32 ;