2-(4-(8-溴-3-甲基-2-氧代-2,3-二氢咪唑并[4,5-C]喹啉-1-基)苯基)-2-甲基丙腈合成路线 （共 8 条）
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water
T=20°C; 72 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2006/122806 A2, 2006 ;
Location in patent: Page/Page column 51 ;
WO 2006/122806 A2
反应条件
1: trichlorophosphate / 0.75 h / 120 °C
2: acetic acid / 2 h
3: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
4: triethylamine / dichloromethane / 1 h / 0 °C
5: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: acetic acid / 2 h
2: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
3: triethylamine / dichloromethane / 1 h / 0 °C
4: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: hydrogen / tetrahydrofuran; methanol / 12 h / 20 °C / 825.08 Torr
2: acetic acid / 2 h
3: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
4: triethylamine / dichloromethane / 1 h / 0 °C
5: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: acetic acid / 2 h
2: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
3: triethylamine / dichloromethane / 1 h / 0 °C
4: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
2: triethylamine / dichloromethane / 1 h / 0 °C
3: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: triethylamine / dichloromethane / 1 h / 0 °C
2: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
1: potassium acetate; acetic anhydride / 1.5 h / 120 °C
2: trichlorophosphate / 0.75 h / 120 °C
3: acetic acid / 2 h
4: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
5: triethylamine / dichloromethane / 1 h / 0 °C
6: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
