2-(4-(6-溴-3-硝基喹啉-4-基氨基)苯基)-2-甲基丙腈合成路线 （共 9 条）
反应条件
in acetic acid T=25°C; 0.5 h;
参考文献
PROGENICS PHARMACEUTICALS, INC.
Patent: WO2009/155527 A2, 2009 ;
Location in patent: Page/Page column 264 ;
WO 2009/155527 A2
反应条件
1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr 2: acetic acid / 2 h View Scheme
参考文献
WO2011/1212 A1, ;
WO 2011/001212 A1
反应条件
1: trichlorophosphate / 0.75 h / 120 °C 2: acetic acid / 2 h View Scheme
参考文献
WO2011/1212 A1, ;
WO 2011/001212 A1
US2012/108627 A1, ;
反应条件
1: potassium acetate / acetic anhydride / 3 h / 120 °C 2: trichlorophosphate / 0.75 h / 120 °C 3: acetic acid / 2 h View Scheme
参考文献
WO2011/1212 A1, ;
WO 2011/001212 A1
反应条件
1: hydrogenchloride / water / 24 h / 20 °C 2: 24 h / 20 °C 3: acetic anhydride; sodium acetate / 2 h / 120 °C 4: trichlorophosphate / 0.75 h / Reflux 5: acetic acid / 2 h / Reflux View Scheme
参考文献
WO2012/116237 A2, ;
WO 2012/116237 A2
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C 2: trichlorophosphate / 0.75 h / 120 °C 3: acetic acid / 2 h View Scheme
反应条件
1: 24 h / 20 °C 2: acetic anhydride; sodium acetate / 2 h / 120 °C 3: trichlorophosphate / 0.75 h / Reflux 4: acetic acid / 2 h / Reflux View Scheme
参考文献
WO2012/116237 A2, ;
WO 2012/116237 A2
反应条件
1: hydrogen / tetrahydrofuran; methanol / 1 h / 825.08 Torr
2: triethylamine / dichloromethane / 1 h / 0 °C
3: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
反应条件
hydrogen; Raney Ni in tetrahydrofuran; methanol
T=20°C; 24 h;
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
Location in patent: Page/Page column 119 ;
WO 2012/116237 A2
