2-(4-(3-氨基-6-溴喹啉-4-基氨基)苯基)-2-甲基丙腈合成路线 （共 10 条）
反应条件
hydrogen; Raney Ni in tetrahydrofuran; methanol
T=20°C; 24 h;
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
Location in patent: Page/Page column 119 ;
WO 2012/116237 A2
反应条件
1: acetic acid / 2 h
2: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; VISHWAKARMA, Ram; MUNDADA, Ramswaroop; DEORE, Vijaykumar; KUMAR, Pramod; SHARMA, Somesh
Patent: WO2011/1212 A1, 2011 ;
WO 2011/001212 A1
反应条件
1: hydrogen / Raney-Ni / tetrahydrofuran; methanol / 10 h / 20 °C / 2068.65 Torr
2: acetic acid / 2 h
3: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; VISHWAKARMA, Ram; MUNDADA, Ramswaroop; DEORE, Vijaykumar; KUMAR, Pramod; SHARMA, Somesh
Patent: WO2011/1212 A1, 2011 ;
WO 2011/001212 A1
反应条件
1: trichlorophosphate / 0.75 h / 120 °C
2: acetic acid / 2 h
3: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; VISHWAKARMA, Ram; MUNDADA, Ramswaroop; DEORE, Vijaykumar; KUMAR, Pramod; SHARMA, Somesh
Patent: WO2011/1212 A1, 2011 ;
WO 2011/001212 A1
反应条件
1: acetic acid / 2 h
2: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; VISHWAKARMA, Ram; MUNDADA, Ramswaroop; DEORE, Vijaykumar; KUMAR, Pramod; SHARMA, Somesh
Patent: WO2011/1212 A1, 2011 ;
WO 2011/001212 A1
反应条件
1: acetic anhydride; potassium acetate / 3 h / 120 °C
2: trichlorophosphate / 0.75 h / 120 °C
3: acetic acid / 2 h
4: hydrogen / Raney-nickel / tetrahydrofuran; methanol / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
Kumar, Sanjay; Vishwakarma, Ram; Mundada, Ramswaroop; Deore, Vijaykumar; Kumar, Pramod; Sharma, Somesh
Patent: US2012/108627 A1, 2012 ;
反应条件
1: potassium acetate / acetic anhydride / 3 h / 120 °C
2: trichlorophosphate / 0.75 h / 120 °C
3: acetic acid / 2 h
4: hydrogen / Raney-Ni / 1 h / 20 °C / 1292.9 Torr
View Scheme
参考文献
PIRAMAL LIFE SCIENCES LIMITED; KUMAR, Sanjay; VISHWAKARMA, Ram; MUNDADA, Ramswaroop; DEORE, Vijaykumar; KUMAR, Pramod; SHARMA, Somesh
Patent: WO2011/1212 A1, 2011 ;
WO 2011/001212 A1
反应条件
1: hydrogenchloride / water / 24 h / 20 °C
2: 24 h / 20 °C
3: acetic anhydride; sodium acetate / 2 h / 120 °C
4: trichlorophosphate / 0.75 h / Reflux
5: acetic acid / 2 h / Reflux
6: hydrogen / Raney Ni / tetrahydrofuran; methanol / 24 h / 20 °C
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: 24 h / 20 °C
2: acetic anhydride; sodium acetate / 2 h / 120 °C
3: trichlorophosphate / 0.75 h / Reflux
4: acetic acid / 2 h / Reflux
5: hydrogen / Raney Ni / tetrahydrofuran; methanol / 24 h / 20 °C
View Scheme
参考文献
INTELLIKINE, LLC; REN, Pingda; LIU, Yi; LI, Liansheng; CHAN, Katrina; WILSON, Troy, Edward; CAMPBELL, Simon, Fraser
Patent: WO2012/116237 A2, 2012 ;
WO 2012/116237 A2
反应条件
1: triethylamine / dichloromethane / 1 h / 0 °C
2: tetrabutylammomium bromide; sodium hydroxide / water; dichloromethane / 72 h / 20 °C
View Scheme
参考文献
NOVARTIS PHARMA AG; INCYTE CORPORATION; VANNUCCHI, Alessandro M.; BOGANI, Costanza; BARTALUCCI, Niccolo
Patent: WO2013/23119 A1, 2013 ;
