4-[(1-氰基-1-甲基乙基)氨基]-2-氟-N-甲基-苯甲酰胺合成路线 （共 5 条）
反应条件
1: in N,N-dimethyl-formamide T=100°C; 11 h; Microwave irradiation; 2: With hydrogenchloride in methanol; N,N-dimethyl-formamide 1.5 h; Heating / reflux;
参考文献
Regents of the University of California
Patent: US2007/254933 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
magnesium sulfate
T=80°C; 12 h;
参考文献
Jung, Michael E.; Ouk, Samedy; Yoo, Dongwon; Sawyers, Charles L.; Chen, Charlie; Tran, Chris; Wongvipat, John
Journal of Medicinal Chemistry, 2010 , vol. 53, # 7 p. 2779 - 2796
参考文献
TONG, Youzhi
Patent: WO2011/29392 A1, 2011 ;
Location in patent: Page/Page column 69 ;
WO 2011/029392 A1
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide / 1 h / -5 °C
1.2: 0 - 25 °C
2.1: acetic acid / iron / ethyl acetate / Reflux
3.1: 12 h / 80 °C
View Scheme
参考文献
TONG, Youzhi
Patent: WO2011/29392 A1, 2011 ;
WO 2011/029392 A1
反应条件
1: acetic acid / iron / ethyl acetate / Reflux
2: 12 h / 80 °C
View Scheme
参考文献
TONG, Youzhi
Patent: WO2011/29392 A1, 2011 ;
WO 2011/029392 A1
