4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫酮-1-咪唑烷基]-2-氟-N-甲基苯甲酰胺合成路线 （共 8 条）
反应条件
1: in N,N-dimethyl-formamide T=100°C; 11 h; Microwave irradiation; 2: With hydrogenchloride in methanol; N,N-dimethyl-formamide 1.5 h; Heating / reflux;
参考文献
Regents of the University of California
Patent: US2007/254933 A1, 2007 ;
Location in patent: Page/Page column 7 ;
反应条件
in isopropanol acetate; dimethyl sulfoxide T=83 - 84°C; 17.5 h;
参考文献
MEDIVATION PROSTATE THERAPEUTICS, INC.; JAIN, Rajendra, Parasmal; ANGELAUD, Remy; THOMPSON, Andrew; LAMBERSON, Carol; GREENFIELD, Scott
Patent: WO2011/106570 A1, 2011 ;
Location in patent: Page/Page column 46 ;
反应条件
T=100°C; 6 h; a sealed-tube;
参考文献
MEDIVATION PROSTATE THERAPEUTICS, INC.; JAIN, Rajendra, Parasmal; ANGELAUD, Remy; THOMPSON, Andrew; LAMBERSON, Carol; GREENFIELD, Scott
Patent: WO2011/106570 A1, 2011 ;
Location in patent: Page/Page column 48 ;
反应条件
1.1: thionyl chloride / N,N-dimethyl-formamide; isopropanol acetate / 4.58 h / 21 - 72 °C / Inert atmosphere; Industry scale 2.1: water; isopropanol acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale 3.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C 3.2: 105 °C / Inert atmosphere 3.3: pH 4 4.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C 4.2: 1.08 h / 32 - 40 °C 5.1: dimethyl sulfoxide; isopropanol acetate / 17.5 h / 83 - 84 °C View Scheme
反应条件
1.1: water; isopropanol acetate / 1.08 h / 2 - 35 °C / Inert atmosphere; Industry scale 2.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C 2.2: 105 °C / Inert atmosphere 2.3: pH 4 3.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C 3.2: 1.08 h / 32 - 40 °C 4.1: dimethyl sulfoxide; isopropanol acetate / 17.5 h / 83 - 84 °C View Scheme
反应条件
1.1: potassium carbonate / copper(l) chloride / N,N-dimethyl-formamide; water / 30 °C 1.2: 105 °C / Inert atmosphere 1.3: pH 4 2.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C 2.2: 1.08 h / 32 - 40 °C 3.1: dimethyl sulfoxide; isopropanol acetate / 17.5 h / 83 - 84 °C View Scheme
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide; water / 30 °C 1.2: 1.08 h / 32 - 40 °C 2.1: dimethyl sulfoxide; isopropanol acetate / 17.5 h / 83 - 84 °C View Scheme
反应条件
1: n-heptane; water / 16.5 h / 5 - 46.4 °C / Industry scale; Inert atmosphere 2: dimethyl sulfoxide; isopropanol acetate / 17.5 h / 83 - 84 °C View Scheme
