1: (S)-4-iodo-1-chloro-2-(4-tetrahydrofuran-3-yloxy-benzyl)-benzene With isopropylmagnesium chloride; lithium chloride in tetrahydrofuran T=-21 - -15°C; 1.83333 h; 2: (3R,4S,5R,6R)-3,4,5-tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one in dichloromethane; acetonitrile T=-25 - -13°C; 2.91667 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '11323438', constants.ctx, '0')">AlCl₃, aluminium chloride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '1733364', constants.ctx, '0')">1,1,3,3-tetramethyldisiloxane</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '635760', constants.ctx, '0')">toluene</a> <br />T=0 - 23&deg;C;&nbsp;2.5&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 &deg;C<br />2: potassium <i>tert</i>-butylate / tetrahydrofuran / 3 h / 16 - 25 &deg;C<br />3: 1,1,3,3-tetramethyldisiloxane / AlCl₃, aluminium chloride / toluene / 2.5 h / 18 - 26 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: potassium <i>tert</i>-butylate / tetrahydrofuran / 3 h / 16 - 25 &deg;C<br />2: 1,1,3,3-tetramethyldisiloxane / AlCl₃, aluminium chloride / toluene / 2.5 h / 18 - 26 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: oxalyl dichloride / N,N-dimethyl-formamide / 5 h / 25 - 30 &deg;C<br />2: potassium <i>tert</i>-butylate / tetrahydrofuran / 3 h / 16 - 25 &deg;C<br />3: 1,1,3,3-tetramethyldisiloxane / AlCl₃, aluminium chloride / toluene / 2.5 h / 18 - 26 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: AlCl₃, aluminium chloride / 1 h / 0 - 25 &deg;C<br />2: potassium <i>tert</i>-butylate / tetrahydrofuran / 0.5 h / 7 - 10 &deg;C<br />3: AlCl₃, aluminium chloride; 1,1,3,3-tetramethyldisiloxane / toluene / 2.5 h / 0 - 23 &deg;C<br /> <br /> &nbsp;