6-氯-5-甲氧基烟酸甲酯合成路线 （共 3 条）
反应条件
1: With methanol; sodium hydroxide; water T=25°C; 24 h; 2: With hydrogenchloride; water in methanol T=0°C; pH=2;
参考文献
Zhu, Yuanming; Loso, Michael R.; Nugent, Benjamin M.; Huang, Jim X.; Rogers, Richard B.
Patent: US2008/108667 A1, 2008 ;
Location in patent: Page/Page column 10 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C;
参考文献
ASTRAZENECA AB
Patent: WO2009/64251 A1, 2009 ;
Location in patent: Page/Page column 140 ;
WO 2009/064251 A1
反应条件
1: N-chloro-succinimide / N,N-dimethyl-formamide / 18 h / 80 °C
2: potassium carbonate / acetone / 5 h / 50 °C
View Scheme
参考文献
PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O'DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani
Patent: WO2011/48525 A1, 2011 ;
WO 2011/048525 A1
