乙基2-甲基-2H-四唑-5-羧酸酯合成路线 （共 6 条）
反应条件
1: With sodium hydroxide; ethanol; water T=20°C; 2 h; 2: With hydrogenchloride; water in ethanol pH=4;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/150015 A1, 2008 ;
Location in patent: Page/Page column 175-176 ;
WO 2008/150015 A1
反应条件
1: With potassium hydroxide; ethanol; water 0.166667 h; 2: With hydrogenchloride; water in ethyl acetate
参考文献
KALYPSYS, INC.
Patent: US2008/139558 A1, 2008 ;
Location in patent: Page/Page column 79 ;
US 20080139558 A1
反应条件
potassium carbonate in acetonitrile
T=20°C; 15 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/150015 A1, 2008 ;
Location in patent: Page/Page column 176 ;
WO 2008/150015 A1
反应条件
sulfuric acid
T=70°C; 4 h;
参考文献
Spear, Robert J.
Australian Journal of Chemistry, 1984 , vol. 37, # 12 p. 2453 - 2468
反应条件
sodium hydroxide in water; acetone
3 h; Heating; Yield given. Title compound not separated from byproducts;
参考文献
Spear, Robert J.
Australian Journal of Chemistry, 1984 , vol. 37, # 12 p. 2453 - 2468
参考文献
Gryszkiewicz-Trochimowski
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1958 , vol. 246, p. 2627
