8-甲氧基-3-二氢色原酮合成路线 （共 7 条）
参考文献
Ciba-Geigy Corporation
Patent: US4604397 A1, 1986 ;
US 4604397 A
反应条件
hydrogenchloride; diphenyl phosphoryl azide; triethylamine
1.) toluene, 80-85 deg C, 1.5 h, 2.) reflux, 2 h; Multistep reaction;
参考文献
Wise, Lawrence D.; DeWald, Horace A.; Hawkins, Elma S.; Reynolds, Donna M.; Heffner, Thomas G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 688 - 691
反应条件
1: aq. NaOH
2: (PhO)2P(O)N3; Et3N; HCl
View Scheme
参考文献
Holmberg, Paer; Sohn, Daniel; Leideborg, Robert; Caldirola, Patrizia; Zlatoidsky, Pavel; Hanson, Sverker; Mohell, Nina; Rosqvist, Susanne; Nordvall, Gunnar; Johansson, Anette M.; Johansson, Rolf
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 3927 - 3930
反应条件
1: 1,4-diazabicyclo[2.2.2]octane
2: aq. NaOH
3: (PhO)2P(O)N3; Et3N; HCl
View Scheme
参考文献
Holmberg, Paer; Sohn, Daniel; Leideborg, Robert; Caldirola, Patrizia; Zlatoidsky, Pavel; Hanson, Sverker; Mohell, Nina; Rosqvist, Susanne; Nordvall, Gunnar; Johansson, Anette M.; Johansson, Rolf
Journal of Medicinal Chemistry, 2004 , vol. 47, # 16 p. 3927 - 3930
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: 3,5-bis(ethoxycarbonyl)-2,6-diethylpyridine 1-oxide; Me4tBuXPhosAuNTf2 / 1,2-dichloro-ethane / 20 °C
View Scheme
参考文献
Wang, Yanzhao; Ji, Kegong; Lan, Sylvester; Zhang, Liming
Angewandte Chemie - International Edition, 2012 , vol. 51, # 8 p. 1915 - 1918
反应条件
sodium acetate; acetic anhydride
Behandeln des Reaktionsprodukts mit methanol. Natronlauge;
参考文献
Richards et al.
Journal of the Chemical Society, 1948 , p. 1610
反应条件
sodium acetate
Behandeln des Reaktionsprodukts mit wss.-methanol. Natronlauge;
参考文献
Richards et al.
Journal of the Chemical Society, 1948 , p. 1610
