1: 1.53 g / K2CO3 / dimethylformamide / 2 h / Ambient temperature 2: 52.1 percent / 1 N NaOH / methanol / 1 h / Ambient temperature 3: 88.9 percent / 47 percent HBr / 9 h / 90 °C 4: 1.) ethyl chloroformate, triethylamine; 2.) Ac2O, fum. HNO3; 3.) NaOH / 1.) THF, 0-5 deg C, 0.5 h; 2.) acetonitrile, -8 deg C, 1 h; 3.) MeOH, H2O, RT, 0.5 h 5: 1 N NaOH / 2 h / 50 °C 6: methanol / 1 h / 70 °C View Scheme

1: 1.53 g / K2CO3 / dimethylformamide / 2 h / Ambient temperature 2: 52.1 percent / 1 N NaOH / methanol / 1 h / Ambient temperature 3: 88.9 percent / 47 percent HBr / 9 h / 90 °C View Scheme

1: 1.53 g / K2CO3 / dimethylformamide / 2 h / Ambient temperature 2: 52.1 percent / 1 N NaOH / methanol / 1 h / Ambient temperature View Scheme

potassium carbonate in N,N-dimethyl-formamide 2 h; Ambient temperature;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098214', constants.ctx, '0')">hydrogenchloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1696894', constants.ctx, '0')">diethyl ether</a> <br />12&nbsp;h;&nbsp;&nbsp;Ambient temperature;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 88.7 percent / 40 percent (w/v) peracetic acid, AcOK / CH₂Cl₂ / 48 h / Ambient temperature<br />2: 90.4 percent / 20 percent (w/v) HCl / diethyl ether / 12 h / Ambient temperature<br /> <br /> &nbsp;