6-羟基-1,2,3,4-四氢异喹啉-1-甲酸合成路线 （共 12 条）
反应条件
1: 75 percent / 55 - 70 °C
2: 98 percent / MeONa / methanol / 12 h / 60 °C
3: 93 percent / K2CO3 / acetone / 12 h / 41 °C
4: 82 percent / LiAlH4 / CH2Cl2; diethyl ether / 0.5 h / Ambient temperature
5: 68 percent / diazabicyclooctane / dioxane / 7 h / 60 °C
View Scheme
参考文献
Anderson, Wayne K.; McPherson, Howard L.; New, James S.; Rick, Arvela C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1321 - 1325
反应条件
1: 75 percent / 55 - 70 °C
2: 98 percent / MeONa / methanol / 12 h / 60 °C
3: 93 percent / K2CO3 / acetone / 12 h / 41 °C
4: 82 percent / LiAlH4 / CH2Cl2; diethyl ether / 0.5 h / Ambient temperature
5: 71 percent / diazabicyclooctane / dioxane / 48 h / 60 °C
View Scheme
参考文献
Anderson, Wayne K.; McPherson, Howard L.; New, James S.; Rick, Arvela C.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 10 p. 1321 - 1325
