4-(羟基甲基)-5-甲基-[1,3]二氧代l-2-酮合成路线 （共 11 条）
反应条件
selenium(IV) oxide in 1,4-dioxane
参考文献
US6054587 A1, ;
US 6054587 A
反应条件
1: With formic acid; triethylamine in acetonitrile T=10 - 65°C; 2: With hydrogenchloride in isopropyl alcohol Reflux; Product distribution / selectivity;
参考文献
JUBILANT LIFE SCIENCES LIMITED; BANSAL, Deepak; MISHRA, Himanchal; DUBEY, Shailendr, Kumar; CHOUDHARY, Alka, Srivastava; VIR, Dharam; AGARWAL, Ashutosh
Patent: WO2012/107814 A1, 2012 ;
Location in patent: Page/Page column 14-15 ;
反应条件
silver nitrate; acetic acid in acetonitrile
反应条件
hydrogenchloride in methanol 5 h; Ambient temperature; Yield given;
参考文献
Synthetic Communications, , vol. 22, # 9 p. 1277 - 1282
反应条件
1: 80 percent / Et3N / acetonitrile / 1 h / Ambient temperature 2: conc. HCl / methanol / 2 h / Ambient temperature View Scheme
参考文献
Synthetic Communications, , vol. 25, # 23 p. 3875 - 3881
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; potassium carbonate; p-toluenesulfonyl chloride in N,N-dimethyl acetamide T=10°C; 3 h; 2: in N,N-dimethyl acetamide pH=5; 3: in water; acetone T=35°C; 2 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2005/187269 A1, 2005 ;
Location in patent: Page/Page column 14 ;
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 4 h;
参考文献
Takeda Pharmaceutical Company Limited
Patent: US2005/187269 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
1: (2-ethoxy-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1H-benzimidazol-7-yl)-carboxyl-4-nitrophenyl sulfonate in dichloromethane T=20 - 30°C; 0.0833333 h; 2: 4-methyl-5-hydroxymethyl-2-oxo-1,3-dioxol-4-ene With 4-(N,N-dimethlyamino)pyridine in dichloromethane T=20 - 45°C; 2 h;
参考文献
RANBAXY LABORATORIES LIMITED; KSHIRSAGAR, Prakash Bhimaji; TIWARI, Anand, Prakash; VERMA, Shyam Sunder; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/42066 A1, 2013 ;
Location in patent: Page/Page column 7 ;
反应条件
1: Azilsartan With 4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 5°C; 0.0833333 h; 2: 4-nitrophenylsulfonyl chloride in dichloromethane T=0 - 30°C; 1 h; 3: 4-methyl-5-hydroxymethyl-2-oxo-1,3-dioxol-4-ene in N,N-dimethyl-formamide T=20 - 40°C; 1 h;
参考文献
RANBAXY LABORATORIES LIMITED; KSHIRSAGAR, Prakash Bhimaji; TIWARI, Anand, Prakash; VERMA, Shyam Sunder; SINGH, Kaptan; PRASAD, Mohan; ARORA, Sudershan, Kumar
Patent: WO2013/42066 A1, 2013 ;
Location in patent: Page/Page column 7; 8 ;
反应条件
1: p-toluenesulfonyl chloride; 4-(N,N-dimethlyamino)pyridine; potassium carbonate / 3 h / 30 °C / |Cooling 2: acetone; water / |Reflux View Scheme
参考文献
ZENTIVA, K.S.; STACH, Jan; KRULIS, Radim; CERNY, Josef; RIDVAN, Ludek; DAMMER, Ondrej; KREJCIK, Lukas; RADL, Stanislav
Patent: WO2014/48404 A1, 2014 ;
