1: With N-ethyl-N,N-diisopropylamine in dichloromethane
T=0 - 20°C; 4 h;
2: With sodium hydrogencarbonate in dichloromethane; water
3: With oxalyl dichloride; N,N-dimethyl-formamide
more than 3 stages;
参考文献
PHARMACIA and UPJOHN COMPANY LLC
Patent: WO2006/126082 A2, 2006 ;
Location in patent: Page/Page column 61 ;