9-氨基-N-(2-吗啉-4-基乙基)吖啶-4-羧酰胺合成路线 （共 5 条）
反应条件
ammonia in phenol
T=115°C; 0.5 h;
参考文献
Wakelin, Laurence P. G.; Bu, Xianyong; Eleftheriou, Alexandra; Parmar, Alpesh; Hayek, Charbel; Stewart, Bernard W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5790 - 5802
反应条件
1: 2.27 g / CH2Cl2 / 2 h / 20 °C
2: 96 percent / NH3 / phenol / 0.5 h / 115 °C
View Scheme
参考文献
Wakelin, Laurence P. G.; Bu, Xianyong; Eleftheriou, Alexandra; Parmar, Alpesh; Hayek, Charbel; Stewart, Bernard W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5790 - 5802
反应条件
1: 2.27 g / CH2Cl2 / 2 h / 20 °C
2: 96 percent / NH3 / phenol / 0.5 h / 115 °C
View Scheme
参考文献
Wakelin, Laurence P. G.; Bu, Xianyong; Eleftheriou, Alexandra; Parmar, Alpesh; Hayek, Charbel; Stewart, Bernard W.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 26 p. 5790 - 5802
反应条件
1: SOCl2, DMF / Heating
2: CH2Cl2 / 30 °C
3: 50 °C
4: NH3 gas / various solvent(s) / 115 °C
View Scheme
参考文献
Atwell; Cain; Baguley; Finlay; Denny
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1481 - 1485
反应条件
1: 83 percent / conc. H2SO4 / 4 h / 100 °C
2: SOCl2, DMF / Heating
3: CH2Cl2 / 30 °C
4: 50 °C
5: NH3 gas / various solvent(s) / 115 °C
View Scheme
参考文献
Atwell; Cain; Baguley; Finlay; Denny
Journal of Medicinal Chemistry, 1984 , vol. 27, # 11 p. 1481 - 1485
