2-(4,7-二甲氧基-1H-吲哚-3-基)-乙胺合成路线 （共 5 条）
反应条件
lithium aluminium tetrahydride in diethyl ether; dichloromethane
T=20°C; 0.5 h;
参考文献
Legentil, Laurent; Benel, Laurent; Bertrand, Viviane; Lesur, Brigitte; Delfourne, Evelyne
Journal of Medicinal Chemistry, 2006 , vol. 49, # 10 p. 2979 - 2988
反应条件
1: acetic acid / H2O / 3 h / 20 °C
2: CH2Cl2; toluene / 20 °C
3: 5.67 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
4: LiAlH4 / diethyl ether; CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Legentil, Laurent; Benel, Laurent; Bertrand, Viviane; Lesur, Brigitte; Delfourne, Evelyne
Journal of Medicinal Chemistry, 2006 , vol. 49, # 10 p. 2979 - 2988
反应条件
1: 70 percent / NH4OAc / 1 h / Heating
2: 84 percent / HCO2NH4 / Pd/C / ethanol / 1 h / Heating
3: 96 percent / POCl3 / 1.5 h / 0 °C
4: 76 percent / NH4OAc / 1 h / Heating
5: LAH / CH2Cl2; diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Beneteau, Valerie; Besson, Thierry
Tetrahedron Letters, 2001 , vol. 42, # 14 p. 2673 - 2676
反应条件
1: CH2Cl2; toluene / 20 °C
2: 5.67 g / tetrabutylammonium fluoride / tetrahydrofuran / 1 h / 20 °C
3: LiAlH4 / diethyl ether; CH2Cl2 / 0.5 h / 20 °C
View Scheme
参考文献
Legentil, Laurent; Benel, Laurent; Bertrand, Viviane; Lesur, Brigitte; Delfourne, Evelyne
Journal of Medicinal Chemistry, 2006 , vol. 49, # 10 p. 2979 - 2988
反应条件
hydrogen; palladium on activated charcoal
参考文献
Hong; Dukat; Teitler; Egan; Dupre; Herrick-Davis; Glennon
Medicinal Chemistry Research, 1999 , vol. 9, # 6 p. 374 - 388
