alpha-氨基吲哚-3-乙酸乙酯合成路线 (共 2 条)
反应条件
lithium hydroxide in water 2 h; Ambient temperature; Yield given;
参考文献
The Upjohn Company
Patent: US5245046 A1, 1993 ;
反应条件
1: 90 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating
2: 94 percent / 18 h / Ambient temperature
3: 98 percent / 5percent K2CO3 / methanol / 2 h / Heating
4: 64 percent / BF3*Et2O / CH2Cl2 / 16 h
5: 97 percent / 1N HCl / methanol / 24 h / 25 °C
6: 66 percent / H2O, paraformaldehyde / tetrahydrofuran / 2 h / Heating
7: TiCl4 / CH2Cl2; diethyl ether / 0.5 h / -78 °C
8: 10percent aq. NaOH / ethanol / 2 h / Heating
View Scheme
参考文献
Katz, Alan H.; Demerson, Christopher A.; Shaw, Chia-Cheng; Asselin, Andre A.; Humber, Leslie G.; et al.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 6 p. 1244 - 1250